Angiotensin II Converting Enzyme (ACE2), Zinc-metalloprotease, is an enzyme involved in Renin-angiotensin System (RAS), which cleaves the C-terminal Dipeptide of Angiotensin II and converts it to Angiotensin 1-7 to control blood pressure. In particular, ACE2, which has been identified as a receptor for Human Coronaviruses (COVID), such as SARS and HCoV-NL63, is expressed in vascular endothelial cells of the lungs, kidneys, and heart, and is currently under much research as a potential therapeutic target for cardiovascular and COVID-induced diseases The PicoSens™ ACE2 Activity Assay Kit utilizes ACE2's ability to release Free Fluorophores by cutting the Synthetic MCA Based Peptide substrate, and the released MCA can be easily quantified to 0.4 mU level with a fluorescent Microplate Reader. We provide an ACE2 Specific Inhibitor that can distinguish ACE2 activity from other proteolytic activities.